Generally, there is a marked decrease in the volume of surface water due to reasons ranging from global warming to anthropogenic activities. The present study evaluated the effect of waste disposal on Nworie River. The potability of the river was studied in terms of bacteriological and physicochemical parameters. A cross-sectional descriptive study design was used. Sample collection from surface and sediment at three different points of the river and at three different times were performed. Conventional microbiological methods of culture, morphological and biochemical assays for isolation and identifications were used. Also, APHA standard analytical methods for the physicochemical assay were employed. Total heterotrophic bacterial count was highest at point A (4.4 x 103 CFU/mL) and lowest at C (3.0 x 101 CFU/mL). Similarly, all other examined bacteria (Coliform, Shigella and Vibrio) were highest at point A and lowest at point C. There was an even distribution of all bacteria both in the surface and sediments across all sampling points A, B and C. Most physical and chemical attributes of the river studied had deviated from acceptable limits for potable water. The domestic and other wastes dumped into Nworie River adversely affected the water body standard. The presence of certain pathogenic bacteria, as well as indicator organisms, has compromised the potability of Nworie River. Further, the physico-chemical properties support the contamination of this water body and suggest unsuitability for human consumption. ______________________________________________________________